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Our research targets are biologically active natural organic compounds. Using synthetic organic chemistry, we aim to elucidate the mechanism of activity expression and structure-activity relationship of physiologically active substances, and to apply them to agricultural chemicals and medicines.
\nOverview: Synthesis and activity evaluation of natural organic compounds and analogues, Elucidation of biosynthetic pathways of physiologically active substances, Application of biocatalysts (microorganisms and enzymes) to organic synthesis, Development of useful organic reactions
\nTarget: antibiotics, plant pathogenic toxins, plant hormones, anorexia, insect attractants; repellents, aroma substances
\nDevelopment: anticancer agents, antitumor agents, antiviral agents (influenza, novel coronavirus, HIV), herbicides, antibiotics, insecticides, perfumeries<\/span><\/p>\n\n
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<\/a>Glycans have attracted much attention as molecules that play various roles in biological recognition, but their detailed functions are still unknown due to their structural complexity and diversity. Therefore, we are investigating efficient synthetic methods for glycans and glycoconjugate derivatives, including the use of enzymes as well as chemical methods. We are also constructing a compound library of alkaloids and heterocyclic compounds, and searching for anti-nematode drugs against pine bark beetles (one of the causes of pine wilt).<\/p>\n","protected":false},"excerpt":{"rendered":"